10 Safest Places to Travel in South America That Will Leave You Amazed (2025)

Explore Cartagena, Colombia

Historical Charm and Safety

Cartagena’s walled city is worth a visit. It’s a UNESCO World Heritage Site with well-preserved colonial architecture and cobblestone streets that give it a unique charm. The public areas are well-lit, and the tourism infrastructure is solid, which helps ensure safety for visitors at all times. With security measures in place in tourist zones, it’s considered one of the safest places to visit in South America. Take a stroll by landmarks like Castillo San Felipe de Barajas, and you’ll see how much they prioritize the well-being of their visitors. And if you’re looking for an itinerary, read about my one week trip to Colombia!

Discover Santiago, Chile.

Stunning Views and Vineyards

The setting of Santiago is unforgettable, surrounded by the majestic Andes mountains that offer stunning views from iconic spots like Cerro San Cristóbal and Cerro Santa Lucía. Just a short drive from the city, we can visit world-class vineyards like Concha y Toro and Santa Rita, where we can enjoy wine tastings and soak in the serenity of the countryside. These activities make Santiago one of the coolest places to travel in South America for wine lovers and nature enthusiasts alike.

Experience Montevideo, Uruguay

Peaceful Atmosphere

Montevideo has a calm and welcoming vibe that stands out among safe travel destinations in South America. Its low crime rates, well-maintained public spaces, and friendly locals make it feel secure for visitors. Known as one of the safest countries to travel in South America, Uruguay ensures that its capital city remains traveler-friendly. Strolling along the Rambla, a picturesque waterfront promenade that stretches over 13 miles, is a favorite activity. Here, we can see locals jogging, cycling, and enjoying the serene views of the coastline. Public parks like Parque Rodó add to the city’s tranquility, offering green spaces perfect for relaxation.

Rich History and Coastal Beauty

Montevideo combines historical significance with stunning coastal views, making it one of the best places to travel to in South America. Its Ciudad Vieja (Old Town) boasts colonial architecture, charming streets, and landmarks like the iconic Solís Theatre and Mercado del Puerto. Visiting Plaza Independencia introduces us to important national monuments, including the mausoleum of General Artigas, a national hero.

The city’s coastal beauty is equally captivating. Beaches like Pocitos and Playa Ramírez provide safe and clean spots for sunbathing and swimming, where both locals and tourists gather peacefully. Montevideo’s unique combination of safety and cultural richness ensures it remains a top choice among safe places to travel in South America.

Visit Buenos Aires, Argentina

Buenos Aires, often called the “Paris of South America”, is undoubtedly one of the safest places in South America for travelers to explore. Its vibrant culture, rich history, and welcoming atmosphere make it a standout among the top 10 places to go in South America.

Safe Neighborhoods to Explore

Buenos Aires is home to several safe neighborhoods perfect for leisurely exploration. Recoleta, known for its elegant architecture and the iconic Recoleta Cemetery, is a must-visit for its serene and secure atmosphere. Palermo, especially Palermo Soho and Palermo Hollywood, is another traveler-friendly area filled with trendy cafes, boutique shops, and leafy parks like the Bosques de Palermo. San Telmo, one of the city’s oldest neighborhoods, is famous for its historic charm and lively Sunday markets, where safety measures and a strong police presence ensure peace of mind for visitors.

Tango, Steaks, and Architecture

Buenos Aires captivates travelers with its world-famous tango, mouthwatering steaks, and stunning European-style architecture. We can enjoy authentic tango performances in places like La Catedral Club or vibrant dinner shows at El Querandí, both located in safe, popular districts. Argentine cuisine, especially its top-tier steaks, shines at reputable parrillas (grill restaurants) like Don Julio, known for both quality and safety. Meanwhile, the city’s architectural gems, including the Casa Rosada and the Teatro Colón, combine beauty with historical significance. This mix of culture, food, and artistry solidifies Buenos Aires as one of the safest and coolest places to travel in South America.

Escape to Cuenca, Ecuador

Colonial Architecture and Safety

Cuenca’s colonial architecture is breathtaking, with cobblestone streets, ornate churches, and colorful plazas echoing its rich historical heritage. Landmarks like the New Cathedral with its iconic blue domes and the historic Old Cathedral showcase the city’s architectural beauty. These well-preserved structures, combined with the city’s friendly community, make Cuenca a memorable destination for exploration.

Safety is one of Cuenca’s strongest attributes, which is why its included on our list of 10 safest places to travel in South America. The city maintains low crime rates, especially in tourist-centered areas such as the historic center, a UNESCO World Heritage Site. Streets are well-lit, and local authorities prioritize visitor safety, making it an excellent choice for worry-free travel.

Popular Expat Destination

Cuenca is also known as one of the most popular expat hubs in South America, often featured among the safest places to live in the region. Thousands of Americans and Europeans have chosen to settle here, drawn by the city’s affordable cost of living, high-quality healthcare, and laid-back lifestyle. This expat presence has helped foster an inclusive, welcoming environment for international travelers.

The city’s vibrant markets, such as Mercado 10 de Agosto, offer a mix of local flavors and handicrafts, while nearby attractions like El Cajas National Park provide stunning outdoor adventures. Whether you’re exploring Cuenca’s rich cultural tapestry or enjoying its tranquil surroundings, it’s clear why this city ranks among the safest places to travel in South America.

Enjoy Punta Arenas, Chile

Punta Arenas is a serene and secure destination, making it one of the safest places to travel in South America. Nestled at the southern tip of Chile, it’s a perfect blend of natural beauty and peaceful charm.

Gateway to Patagonia

Punta Arenas serves as the gateway to Patagonia, one of the coolest places to travel in South America for outdoor enthusiasts. The city provides access to stunning parks like Torres del Paine, renowned for its dramatic landscapes of mountains, glaciers, and turquoise lakes. Visitors can embark on breathtaking hikes, glacier tours, and wildlife spotting adventures, making it a must-see stop for exploring southern Chile.

Calm and Secure Small City

As a small city, Punta Arenas offers a calm and safe atmosphere for travelers. The low crime rate and friendly locals create a welcoming environment for visitors. The city is well-lit and easy to navigate, with secure neighborhoods and walkable streets. Its unique landmarks, like the iconic Plaza Muñoz Gamero and the Strait of Magellan views, add to its appeal as a safe place to explore.

Wander Around Salta, Argentina

Salta, located in northern Argentina, is a gem combining natural beauty, colonial charm, and a secure atmosphere. It’s one of the safest places to travel in South America, with its friendly locals and well-preserved heritage making it an ideal spot for exploration.

Picturesque and Safe City

Salta offers stunning views, colonial architecture, and a relaxed ambiance that makes it feel welcoming. The city has low crime rates, especially in tourist-heavy areas like the central plaza and nearby museums. Known as “Salta la Linda” (Salta the Beautiful), it’s easy to understand why it’s included among the safest places in South America to visit. Charming Streets and Mountains

Wandering through Salta’s cobblestone streets reveals colorful facades, historic churches, and lively markets. The city serves as a hub for exploring dramatic mountain ranges like the Andes and breathtaking landscapes such as Quebrada de Humahuaca. Taking a ride on the Tren a las Nubes (Train to the Clouds) gives both remarkable views and a safe way to experience the region. For outdoor enthusiasts, Salta is a gateway to unique places to visit in South America, known for its serene environment and tourist-friendly infrastructure.

Adventure in Arenal Volcano Area, Costa Rica

Located in the heart of Costa Rica, the Arenal Volcano Area offers thrilling adventures amidst lush natural surroundings; a great addition to our list of 10 safest places to travel in South America.

Natural Beauty and Security

Arenal Volcano is the centerpiece of this region, towering over the landscape with its symmetrical cone. The surrounding Arenal Volcano National Park features pristine hiking trails, waterfalls, and wildlife such as toucans and monkeys, creating a paradise for nature lovers. Security measures in the area are notable, with well-regulated park access and guides available to ensure a worry-free visit. Nearby towns like La Fortuna are particularly safe, with friendly locals and a strong police presence, making it easy to explore the region.

Eco-Tourism Excellence

This area is a global leader in eco-tourism and sustainable travel, making it one of the best places to visit if you value environmental conservation. Activities like zip-lining through the canopy, soaking in natural hot springs, and horseback riding are both eco-friendly and adventure-filled. Resorts and lodges in the region prioritize safety and sustainability, offering amenities such as guided tours and environmentally-conscious practices.

Relax in Valparaíso, Chile

Often called the cultural capital of Chile, Valparaíso is one of the safest places to travel in South America to experience an artistic and vibrant city. With friendly locals and a welcoming atmosphere, this coastal gem provides peace of mind for travelers exploring its unique streets.

Artistic City and Safety

Valparaíso is renowned for its vibrant art scene, making it a unique place to visit in South America. Its safety measures, particularly in tourist areas like Cerro Alegre and Cerro Concepción, ensure that visitors can explore without concern. These neighborhoods boast colorful murals, creative galleries, and trendy cafes, creating an inspiring environment for exploring safely.

Colorful Houses and Hills

Valparaíso’s iconic hills, covered in brightly painted houses, are among its most photographed features. The labyrinth of steep streets and funicular elevators provides scenic views of the Pacific Ocean. This city is a standout for safe travel in South America, as these picturesque areas are well-frequented by tourists and locals alike. From cozy hillside corners to charming street art, Valparaíso is a secure and picturesque spot for a South American getaway.

Explore The Galápagos Islands, Ecuador

The Galápagos Islands, one of the safest places to travel in South America, offer an extraordinary mix of isolation and natural beauty. This UNESCO World Heritage site is unparalleled for its unique wildlife and strict conservation measures.

10 Safest Places to Travel In South America: Isolated and Highly Regulated

The Galápagos Islands’ remote location in the Pacific Ocean makes them one of the safest places to visit in South America. Ecuador strictly regulates access to the archipelago, minimizing crowding and ensuring the security of all visitors. Tourists must pass through multiple checks, including specific entry permits and inspections at airports, to preserve the islands’ biodiversity. Only licensed tour operators are allowed, contributing to a highly organized and controlled environment.

Wildlife Wonders

Home to iconic species like giant tortoises, blue-footed boobies, and marine iguanas, the Galápagos Islands provide unmatched opportunities to experience wildlife up close. Exploring the islands on small guided tours ensures an intimate and secure way to encounter the animals in their natural habitats. Dive into crystal-clear waters alongside sea lions and reef sharks while knowing safety standards are rigorously maintained. The Galápagos also stands out among the safest places to travel South America because park rangers and guides prioritize visitor well-being while protecting the fragile ecosystem. This destination merges safety and adventure, making it one of the top 10 places to go in South America.

10 Safest Places To Travel In South America

South America offers a wealth of destinations where safety and unforgettable experiences go hand in hand. From vibrant cities to serene natural wonders, travelers can explore with confidence while immersing themselves in the region’s rich cultures and breathtaking landscapes.